|
KMID : 0043320010240060578
|
|
Archives of Pharmacal Research
2001 Volume.24 No. 6 p.578 ~ p.583
|
|
|
In vitro Percutaneous Absorption of Tenoxicam from Pressure-sensitive Adhesive Matrices across the Hairless Mouse Skin
|
|
Gwak HS
Chun IK
|
|
|
Abstract
|
|
|
|
To investigate the feasibility of developing a new tenoxicam plastery the effects of vehicles and penetration enhancers on the in vitro permeation of tenoxicam from a pressure-s entitiye adhesive (PSA) matrices across the dorsal hairless mouse strain were studied. Vehicles employed in this study were propylene glycol (PC)-oleyl alcohol (OAI), PC-oleic acid (OA), and diethylene g1yco1 monoethyl ether (DCMI)-propylene glycol monolaurate (PCML) cosolvents with/without fatly acids. In this study, amines such as triethanolamine (TEA) and tromethamine (TM) were additionally used as a solubilized. Among PSAs used, Duro-TakR 87-2510 showed much higher release rate than either Duro-Take 87-2100 or Duro-TakR 87-2176. The relatively high flux rate was obtained with the formulation of DGME-PGML (40:60, v/v) with 3% OA and 5% TM, and the flux increased as a function of the dose; the initial flux up to 12 h was 4.78±1.387g/cm7/h at the tenoxicam dose of 50 mg/70cm2. This flux was much higher than that of a commercial piroxicam patch (TrastR ) (1.24 ± 0.737mcg/cm2/hr) with almost only one-third that of the commercial patch. Therefore, these observations indicated that these composition of tenoxicam plaster may be practically applicable.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|